|
KMID : 0363620150360030073
|
|
Journal of Korean Oriental Medicine
2015 Volume.36 No. 3 p.73 ~ p.83
|
|
|
Effects of Polyporus Herbal-acupuncture at KI10 on LPS-induced nephritis in rats
|
|
Lee Jeong-Yun
Jang Seung-Hoon
Jeon Jong-Ik
Yim Yun-Kyoung
|
|
|
Abstract
|
|
|
Objectives: The purpose of this study was to evaluate the effects of Polyporus Herbal-acupuncture(PO-HA) at KI10
(Umgok) on nephritis induced by lipopolysaccharide(LPS) in rats.
Methods: Rats were allocated into normal, control, and 2 experimental groups. The rats in the control group were intra-peritoneally injected with LPS for nephritis induction. The rats in the groups of experiment 1 and experiment 2 were treated with Saline injection, and PO-HA, respectively at KI10 three times for a week and then intra-peritoneally injected with LPS. To evaluate the effects of PO-HA at KI10, WBC count in blood, creatine, tumor necrosis factor-alpha (TNF-α), cytokine-induced neutrophil chemoattractant 1(CINC-1) in serum, urinary volume, creatinine, total protein in urine, myeloperoxidase(MPO) in kidney were measured.
Results: PO-HA at KI10 significantly suppressed the increase of WBC in blood, TNF-α, CINC-1 in serum, MPO in kidney of LPS-stimulated rats. PO-HA at KI10 significantly suppressed the increase creatinine, total protein in urine of LPS-stimulated rats.
Conclusions: According to these results, it is postulated that PO-HA at KI10 has an anti-inflammatory and renal-protective effects on LPS-induced nephritis in rats. Therefore, it is suggested that PO-HA at KI10 may be an useful therapeutics for nephritis in clinical field after further researches.
|
|
|
KEYWORD
|
|
|
LPS-induced nephritis, Polyporus Herbal-acupuncture, KI10
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|